08 Mar 2010
The relevance of growth factors to the pathogenesis of human cancer has long been established. Among the growth factors and growth factor receptors that have been shown to be involved in the pathogenesis and progression of different carcinoma types is the epidermal growth factor (EGF) family of peptide growth factors and the EGF receptor. Growth hormone (GH) has been previously described to regulate hepatic EGFR expression.
Gonzales et al. analyzed EGF signaling pathways in two different in vivo models: one resistant to the actions of and the other with increased circulating GH levels (transgenic mice overexpressing bovine GH). Their study provides evidence not only for the crosstalk between GH and EGF signaling in the liver but also for different mechanisms controlling EGF-induced signaling pathways. Gonzales et al., Journal of Endocrinology.
