Evidence increasingly demonstrates of role for prolactin (PRL) in the pathogenesis of human breast cancer. Cyclophilin B (CypB) is a binding partner necessary for the transactivation of PRL-responsive genes involved in breast cancer.
In this study, Fang and colleagues used siRNA to examine the effect of CyB knockdown in PRL-stimulated breast cancer cells. They conclude that the absence of CypB significantly impairs PRL-induced gene expression in breast cancer cells, resulting in reduced cell growth and migration. Fang, F
et al. (2010).
Journal of Molecular Endocrinology,
44, 319-329.
DOI: 10.1677/JME-09-0140