03 Aug 2010
In their recent study, Ronda et al. show that extracellular regulated kinase (ERK) and p38 mitogen-activated protein kinases (p38 MAPKs) play a role in mediating the protective effects of E2 in apoptosis. When inhibitors of ERK and p38 MAPK were present, H2O2-induced apoptosis was not prevented by E2, leading to alterations in the intracellular distribution of the murine C2C12 skeletal cell line which are typical of apoptosis. Ronda et al. (2010) Journal of Endocrinology 206, 235-246.
Read full article at DOI:10.1677/JOE-09-0429